期刊
JOURNAL OF VIROLOGY
卷 78, 期 9, 页码 4927-4930出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.9.4927-4930.2004
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Mice depleted of gammadelta T cells by in vivo administration of anti-TCRgammadelta monoclonal antibodies showed susceptibility against an intravaginal infection with herpes simplex virus type 2 (HSV-2). The systemic Th1 response was impaired in the gammadelta T-cell-depleted mice. Mice deficient in the Vdelta1 T subset were susceptible to an intravaginal infection with HSV-2. Intraepithelial gammadelta T cells bearing Vdelta1 may help protect against intravaginal infection with HSV-2 through promoting the systemic Th1 response.
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