期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 9, 期 -, 页码 1254-1266出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/1239
关键词
endothelial; integrin; signaling; focal adhesion kinase; proline-rich tyrosine kinase-2; review
资金
- NHLBI NIH HHS [T32 HL07918, HL44575] Funding Source: Medline
Endothelial cells form a continuous single layer lining throughout the vascular tree. Such positioning allows the endothelium to monitor numerous environmental signals within the blood vessel, including blood composition, structural matrix, and blood flow dynamics. Following signal integration, endothelial cells then induce context - specific changes in vessel properties. The nonreceptor tyrosine kinases focal adhesion kinase (FAK) and proline-rich tyrosine kinase-2 (Pyk2) are activated by integrins, growth factors, and mechanical stimuli, suggesting a potentially important role in the integration of environmental stimuli. This review will explore the current understanding of FAK and Pyk2 signaling in endothelial regulation of vascular function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据