期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 12, 期 9, 页码 1991-1994出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.03.005
关键词
cytotoxic; quinazolino-beta-carboline-5-one derivatives
A novel series of quinazolino-beta-carbolinone derivatives was synthesized and evaluated for their in vitro and in vivo anticancer activity. Many compounds have shown good in vitro activity in the range 1-8 muM concentration. Three of the compounds were further tested in nude mice bearing HT-29 colon cancer xenografts. (C) 2004 Elsevier Ltd. All rights reserved.
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