期刊
JOURNAL OF IMMUNOLOGY
卷 172, 期 9, 页码 5154-5157出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.172.9.5154
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IL-21 is a cytokine that regulates the activation of T and NK cells and promotes the proliferation of B cells activated via CD40. In this study, we show that rIL-21 strongly induces the production of all IgG isotypes by purified CD19(+) human spleen or peripheral blood B cells stimulated with anti-CD40 mAb. Moreover, it was found to specifically induce the production of IgG(i) and JgG(3) by CD40-activated CD19(+)CD27(-) naive human B cells. Although stimulation of CD19+ B cells via CD40 alone induced gamma1 and gamma3 germline transcripts, as well as the expression of activation-induced cytidine deaminase, only stimulation with both anti-CD40 mAb and rIL-21 resulted in the production of Sgamma/Smu switch circular DNA. These results show that IL-21, in addition to promoting growth and differentiation of committed B cells, is a specific switch factor for the production of IgG(1) and IgG(3).
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