期刊
MOLECULAR IMAGING AND BIOLOGY
卷 6, 期 3, 页码 149-159出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mibio.2004.03.002
关键词
phantom; simulation; single-photon emission computed tomography; computed tomography
资金
- NCRR NIH HHS [P41 RR05959] Funding Source: Medline
PURPOSE: We develop a realistic and flexible 4-D digital mouse phantom and investigate its usefulness in molecular imaging research. METHODS: Organ shapes were modeled with non-uniform rational B-spline (NURBS) surfaces based on high-resolution 3-D magnetic resonance microscopy (MRM) data. Cardiac and respiratory motions were modeled based on gated magnetic resonance imaging (MRI) data obtained from normal mice. Pilot simulation studies in single-photon emission computed tomography (SPELT) and X-ray computed tomography (CT) were performed to demonstrate the utility of the phantom. RESULTS: NURBS are an efficient and flexible way to accurately model the anatomy and cardiac and respiratory motions for a realistic 4-D digital mouse phantom. The phantom is capable of producing realistic molecular imaging data from which imaging devices and techniques can be evaluated. CONCLUSION: The phantom provides a unique and useful tool in molecular imaging research. It can be used in the development of new imaging instrumentation, image acquisition strategies, and image processing and reconstruction methods. (C) 2004 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据