期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 5, 期 5, 页码 343-354出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1366
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- Biotechnology and Biological Sciences Research Council [B18672, BBS/B/07683] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [B18672, BBS/B/07683] Funding Source: Medline
The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man. Recent studies have shown that this factor is regulated by an unprecedented signalling mechanism that involves post-translational hydroxylation. This hydroxylation is catalysed by a set of non-haem, Fe2+-dependent enzymes that belong to the 2-oxoglutarate-dependent-oxygenase superfamily. The absolute requirement of these enzymes for molecular oxygen has provided new insights into the way cells sense oxygen.
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