期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 48, 期 5, 页码 1908-1911出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.5.1908-1911.2004
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资金
- NIAID NIH HHS [N01AI30041] Funding Source: Medline
We developed a novel model of invasive aspergillosis (IA) that recapitulates human disease. Mice were immunosuppressed with cyclophosphamide and cortisone acetate and then infected in an aerosol chamber. This procedure reproducibly delivered 1x10(3) to 3x10(3) conidia to the lungs. Lethal pulmonary IA developed over 2 weeks and was prevented by amphotericin B.
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