期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 48, 期 5, 页码 1807-1810出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.5.1807-1810.2004
关键词
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资金
- NIAID NIH HHS [R01 AI045957, AI45957, AI056312, R01 AI056312] Funding Source: Medline
We report on the development of a new SYBR Green I-based plate assay for analyzing the activities of antimalarial drugs against intraerythrocytic Plasmodium falciparum. This assay is considerably faster, less labor-intensive, and less expensive than conventional radiotracer (e.g., [H-3]hypoxanthine and [H-3]ethanolamine)-based assays or P. falciparum lactate dehydrogenase activity-based assays. The assay significantly improves the pace at which antimalarial drug discovery efforts may proceed.
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