期刊
BIOLOGICAL PSYCHIATRY
卷 55, 期 9, 页码 897-903出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2004.01.007
关键词
amygdala; functional magnetic resonance imaging; human; state anxiety; happy faces; neutral faces
资金
- NIMH NIH HHS [MH-01866] Funding Source: Medline
Background. Previous functional imaging studies demonstrating amygdala response to happy facial expressions have all included the presentation of negatively valenced primary comparison expressions within the experimental context. This study assessed amygdala response to happy and neutral facial expressions in an experimental paradigm devoid of primary negatively valenced comparison expressions. Methods: Sixteen human subjects (eight female) viewed 16-sec blocks of alternating happy and neutral faces interleaved with a baseline fixation condition during two functional magnetic resonance imaging scans. Results: Within the ventral amygdala, a negative correlation between happy versus neutral signal changes and state anxiety was observed, The majority of the variability associated with this effect was explained by a positive relationship between state anxiety and signal change to neutral faces. Conclusions. Interpretation of amygdala responses to facial expressions of emotion will be influenced by considering the contribution of each constituent condition within a greater subtractive finding, as well as 1) their spatial location within the amygdaloid complex; and 2) the experimental context in which they were observed. Here, an observed relationship between state anxiety and ventral amygdala response to happy versus neutral faces was explained by response to neutral faces.
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