期刊
ATHEROSCLEROSIS
卷 174, 期 1, 页码 99-103出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2004.01.010
关键词
atherosclerosis; hepatitis B; hepatitis C; study of health in Pomerania (SHIP)
Background: The development of atherosclerosis has an inflammatory component. Currently it is not clear, whether hepatitis B and C virus infections are associated with the risk of atherosclerosis. The aim of the present analysis was to investigate those relationships in a population sample. Methods and results: The study of health in Pomerania (SHIP) is a cross-sectional study of the adult population in the northeast of Germany. HBs antigen (HBsAg) and IgG antibodies against hepatitis B and C virus (anti-HBs and anti-HCV) were determined by enzyme linked immunosorbent assays. Fifteen subjects (0.4%) were positive for HBsAg, and 21 subjects (0.5%) were positive for anti-HCV. Among the persons who had no history of anti-hepatitis B vaccination, 213 individuals (5.0%) were found to be as positive for anti-HBs. These individuals and those with prevalent anti-HCV antibodies were regarded as cases (n = 233). The control group comprised of 4033 individuals. Multivariable analyses revealed that there was no independent association between anti-HBs and anti-HCV antibody seropositivity and atherosclerotic end-points such as prevalent myocardial infarction, stroke, carotid intima-media thickness (IMT), carotid plaques and stenoses. Conclusion: There is no association between serological markers for hepatitis B and C virus infection and the risk of atherosclerosis in this population sample. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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