期刊
TRENDS IN NEUROSCIENCES
卷 27, 期 5, 页码 235-238出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2004.03.002
关键词
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资金
- NINDS NIH HHS [R37 NS027036] Funding Source: Medline
Amyotrophic lateral sclerosis (ALS) is a fatal, progressive neurodegenerative disease that kills motor neurons. Despite a long disappointing history of human trials with neurotrophins, including insulin-like growth factor 1 (IGF-1), Kaspar and colleagues have successfully slowed disease in transgenic ALS mice by forcing motor neurons to produce IGF-1 following retrograde delivery of recombinant adeno-associated virus (AAV) injected into muscle. With the clinical safety of both IGF-1 and AAV already established, this provides real hope for an effective treatment of ALS.
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