期刊
MAGNETIC RESONANCE IN MEDICINE
卷 51, 期 5, 页码 945-952出版社
WILEY
DOI: 10.1002/mrm.20048
关键词
proton exchange; WEX; CEST; APT; magnetization transfer; mobile protein; amide proton; ischemia; pH imaging
资金
- NIBIB NIH HHS [EB02666, P41 EB015909] Funding Source: Medline
- NINDS NIH HHS [NS13490] Funding Source: Medline
The proton exchange processes between water and solutes containing exchangeable protons have recently become of interest for monitoring pH effects, detecting cellular mobile proteins and pepticles, and enhancing the detection sensitivity of various low-concentration endogenous and exogenous species. In this work, the analytic expressions for water exchange (WEX) filter spectroscopy, chemical exchange-dependent saturation transfer (CEST), and amide proton transfer (APT) experiments are derived by the use of Bloch equations with exchange terms. The effects of the initial states for the system, the difference between a steady state and a saturation state, and the relative contributions of the forward and backward exchange processes are discussed. The theory, in combination with numerical calculations, provides a useful tool for designing experimental schemes and assessing magnetization transfer (MT) processes between water protons and solvent-exchangeable protons. As an example, the case of endogenous amide proton exchange in the rat brain at 4.7 T is analyzed in detail. Magn Reson Med 51:945-952, 2004. (C) 2004 Wiley-Liss, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据