期刊
TETRAHEDRON
卷 60, 期 19, 页码 4295-4302出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2004.03.025
关键词
domino reactions; [4+1] cycloaddition reactions; retro ene reaction; lipophilic building blocks
Preparatively simple, one-pot syntheses of trifluoromethyl-substituted hydantoins starting from Boc-protected imines of hexafluoroacetone and trifluoropyruvate are described. They represent valuable building blocks for the construction of constrained peptides or as scaffolds for the synthesis of highly potent VLA-4 antagonists. (C) 2004 Elsevier Ltd. All rights reserved.
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