期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 9, 页码 2035-2040出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.02.057
关键词
inverse electron demand (IED) Diels-Alder reaction; chiral salen-AICI complex; diastereomeric excess; pyranoquinolines; bactericidal and bacteriolytic agents
The first, target-oriented synthesis of pyranoquinolines as potential antibacterial agents by inverse electron demand (IED) Diels-Alder reaction using chiral salen-AlCl complex has been accomplished, the reactions proceed with moderate yields, and a very high degree of diastereoselectivity (>90%). The diastereoselectivity-enhanced pyranoquinolines exhibit potential bactericidal activity against seven strains of pathogenic grain-negative bacteria. (C) 2004 Elsevier Ltd. All rights reserved.
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