期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 9, 页码 2047-2050出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.02.056
关键词
glucagon receptor antagonists; hepatic glucose production inhibitors
Biaryl amides derived from a reported series of ureas 1 were evaluated and found to be potent human glucagon receptor antagonists. The benzofuran analogue 6i was administered in Sprague-Dawley rats and blocked the effects of an exogenous glucagon challenge. (C) 2004 Elsevier Ltd. All rights reserved.
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