期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 199, 期 9, 页码 1285-1291出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20032158
关键词
suppressor cells; autoimmune polyendocrinopathies; Addison's disease; type I diabetes; autoimmune thyroiditis
In autoimmune polyglandular syndromes (APS), several organ-specific autoimmune diseases, are clustered. Although APS type I is caused by loss of central tolerance, the etiology of APS type II (APS-II) is currently unknown, However, in several murine models, depletion of CD4(+) CD25(+) regulatory T cells (T-regs) causes a syndrome resembling human APS-II with multiple endocrinopathies. Therefore, we hypothesized that loss of active suppression in the periphery could be a hallmark of this syndrome. T-regs from peripheral blood of APS-II, control patients with single autoimmune endocrinopathies, and normal healthy donors showed no differences in quantity (except for patients with isolated autoimmune diseases), in functionally important surface markets, or in apoptosis induced by growth factor withdrawal. Strikingly, APS-II T-regs were defective in their suppressive capacity. The defect was persistent and not due to responder cell resistance. These data provide novel insights into the pathogenesis of APS-II and possibly human autoimmunity in general.
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