期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 199, 期 9, 页码 1179-1190出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20040274
关键词
var gene; plasmodium filciparum; malaria; PfEMP1; antibody selection
Parasite-encoded variant surface antigens (VSAs) like the var gene-encoded Plasmodium falciparum erythrocyte membrane protein 1 (PfFMP1) family are responsible for antigenic variation and infected red blood cell (RBC) cytoadhesion in P.falciparum malaria. Parasites causing severe malaria in nonimmune patients tend to express a restricted subset of VSA (VSA(SM)) that differs from VSA associated With uncomplicated malaria and asymptomatic Infection (VSA(UM)). We compared var gene transcription in unselected P. falciparum clone 3D7 expressiring VSA(UM) to in vitro-selected sublines expressing VSA(SM) to identify PfEMP1 responsible for the VSA,, phenotype. Expression of VSA(SM) Was accompanied by up-regulation of Group A var genes. The most prominently up-regulated Group A gene (PFD1235u/MAL7P1.1) was translated into a protein expressed oil the infected RBC surface. The proteins encoded by Group A var genes, such as PFD1233w/MAL7P1.1, appear to be involved in the pathogenesis of severe disease and are thus attractive candidates for a vaccine against life-threatening P.falciparum malaria.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据