期刊
SYNLETT
卷 -, 期 6, 页码 1003-1006出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-2004-822906
关键词
amino acids; condensation; cyclizations; heterocycles; peptides
Efficient synthesis of a conformationally preorganized C-3-symmetric molecular platform is reported. The rigid scaffold is based on the structure of marine cyclopeptides and presents three functional groups pointing in the same direction. The bicyclic imidazole building blocks were synthesized in seven steps from trans-4-hydroxy-(S)-proline.
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