期刊
JOURNAL OF THEORETICAL BIOLOGY
卷 228, 期 1, 页码 55-80出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jtbi.2003.12.004
关键词
Helicobacter pylori; gastric acid; persistence; mathematical model
资金
- NHLBI NIH HHS [1R01 HL62119] Funding Source: Medline
We present a comprehensive mathematical model describing Helicobacter pylori interaction with the human gastric acid secretion system. We use the model to explore host and bacterial conditions that allow persistent infection to develop and be maintained. Our results show that upon colonization, there is a transient period (day 1-20 post-infection) prior to the establishment of persistence. During this period. changes to host gastric physiology occur including elevations in positive effectors of acid secretion (such Lis astrin and histamine). This is promoted by reduced somatostatin levels, an inhibitor of acid release. We suggest that these changes comprise compensatory mechanisms aimed at restoring acid to pre-infection levels. We also show that ammonia produced by bacteria sufficiently buffers acid promoting bacteria survival and growth. (C) 2003 Elsevier Ltd. All rights reserved.
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