期刊
TETRAHEDRON LETTERS
卷 45, 期 20, 页码 3941-3943出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.03.089
关键词
total synthesis; nothapodytine B; mappicine; Johnson orthoester rearrangement; pyridon.
A novel, efficient total synthesis of the naturally occurring antiviral nothapodytine B (2, mappicine ketone) is reported. The approach is based on the successful implementation of the Johnson orthoester rearrangement of allylic alcohol 7 for assembly of a pyridone D ring precursor with the necessary functionalities. Nothapodytine B is converted into mappicine 3 by NaBH4 reduction. (C) 2004 Elsevier Ltd. All rights reserved.
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