期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 101, 期 19, 页码 7369-7374出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0402248101
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资金
- Intramural NIH HHS [Z01 HL004233] Funding Source: Medline
- NCI NIH HHS [CA 68484, P01 CA068484, CA 06516, P30 CA006516] Funding Source: Medline
- NHLBI NIH HHS [R01 HL048801, HL 04233-04, K08 HL004233, R01 HL 48801-09] Funding Source: Medline
- NIDDK NIH HHS [1R21 DK 063660-02] Funding Source: Medline
Transgenic zebrafish that express GFP under control of the T cell-specific tyrosine kinase (Ick) promoter were used to analyze critical aspects of the immune system, including patterns of T cell development and T cell homing after transplant. GFP-labeled T cells could be ablated in larvae by either irradiation or dexamethasone added to the water, illustrating that T cells have evolutionarily conserved responses to chemical and radiation ablation. In transplant experiments, thymocytes from Ick-GFP fish repopulated the thymus of irradiated wild-type fish only transiently, suggesting that the thymus contains only short-term thymic repopulating cells. By contrast, whole kidney marrow permanently reconstituted the T lymphoid compartment of irradiated wild-type fish, suggesting that long-term thymic repopulating cells reside in the kidney.
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