期刊
JOURNAL OF INFECTIOUS DISEASES
卷 189, 期 10, 页码 1921-1925出版社
OXFORD UNIV PRESS INC
DOI: 10.1086/386284
关键词
-
资金
- NIAID NIH HHS [R01 AI41213] Funding Source: Medline
Anaplasma phagocytophilum is an obligate intracellular bacterium that infects neutrophils and causes human anaplasmosis ( formerly human granulocytic ehrlichiosis). Interferon (IFN) -gamma causes immunopathology in A. phagocytophilum infection models. Plasma IFN-gamma levels are elevated 4 h after infection in experimentally infected mice, which indicates innate immunity and possible Toll-like receptors (TLRs). The ability of A. phagocytophilum to trigger proinflammatory responses via nuclear factor (NF)-kappaB was tested in TLR2- and TLR4-transfected cell lines and in primary murine macrophages devoid of TLR2 or TLR4. NF-kappaB was activated only through TLR2, which suggests its role in innate immune induction with A. phagocytophilum infections. The role of innate immunity in human anaplasmosis immunopathology requires more study.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据