期刊
JOURNAL OF PHYSIOLOGY-LONDON
卷 557, 期 1, 页码 191-205出版社
WILEY
DOI: 10.1113/jphysiol.2004.062174
关键词
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资金
- NIDDK NIH HHS [R01 DK062267, DK62267, F32DK60382, F32 DK060382] Funding Source: Medline
- NINDS NIH HHS [R01 NS026995, NS26995] Funding Source: Medline
We have previously demonstrated that trinitrobenzene sulphonic acid (TNBS)-induced colitis in guinea pig is associated-with hyperexcitability-of myentericAH neurones, enhanced synaptic activity in the myenteric plexus, increased serotonin (5-HT) availability in the mucosa, and decreased propulsive motor activity. The current study tested the hypothesis that the activation of cyclooxygenase (COX) contributes to these alterations in bowel functions. DFU inhibition of COX-2, but not SC-560 inhibition of COX- 1, restored to normal levels the electrical properties of myenteric AH neurones, the proportion of S neurones exhibiting slow EPSPs, and the rate of propulsive motor activity. Neither inhibitor was effective in altering the level of inflammation, the increased availability of mucosal 5-HT, or the enhanced fast EPSPs in myenteric AH and S neurones. COX-2 expression is enhanced in the myenteric plexus and cells within the smooth muscle layers during colitis, possibly reflecting the site at which COX-2 inhibition acts to allow recovery of motor function. In support of this concept, COX-1, but not COX-2, inhibition was effective in restoring normal mucosal prostaglandin levels. These results indicate that the various changes that occur in the motor neural pathways of the distal colon in TNB-Sinduced colitis do not involve a single neuroimmune mechanism. COX-2 activation is a critical step in the enhanced excitability of AH neurones as well as diminished propulsive motility in TNBS colitis, whereas other yet to be resolved pathways, that do not involve COX- 1 or COX-2 activation, lead to altered 5-HT content in the mucosa and an augmentation of fast EPSPs.
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