期刊
COLLOIDS AND SURFACES B-BIOINTERFACES
卷 35, 期 2, 页码 81-91出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2004.02.012
关键词
copolymer; micelle; drug-delivery; poly(caprolactone); polymerization
A series of short block length methoxy poly(ethylene glycol)-block-poly(caprolactone) diblock copolymers was synthesized and characterized in order to assess the potential of these copolymers as a micellar drug-delivery system. Varying the caprolactone:MePEG weight ratio in the reaction mixture allowed the synthesis of diblock copolymers with a MePEG molecular weight of 750 g/mol and PCL block lengths of 2, 5 or 10 repeat units. Phase diagrams of aqueous solutions of the copolymers were constructed which displayed characteristic cloud points and Krafft points. As the degree of polymerization of PCL increased, critical micelle concentration (CMC) values decreased from 6.97 x 10(-1) to 3.38 x 10(-3) g/l, partition equilibrium coefficients (K-v) increased from 1.09 x 10(4) to 22.2 x 10(4), and hydrodynamic diameters increased from 12.2 to 19.5 nm. The micelle morphology was determined to be spherical by transmission electron microscopy. (C) 2004 Elsevier B.V. All rights reserved.
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