期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 12, 期 10, 页码 2603-2616出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.03.021
关键词
H-3 antagonist; cinnamic amides; diamine; cytochrome P450
New imidazole-free H-3 antagonists have been found in a series of cinnamic amides of (S)-(aminomethyl)pyrrolidines. The influence of the substituent on the aromatic moiety on the potency and the inhibition of three cytochrome P450 subtypes are also described. (C) 2004 Elsevier Ltd. All rights reserved.
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