期刊
FEBS LETTERS
卷 566, 期 1-3, 页码 173-177出版社
WILEY
DOI: 10.1016/j.febslet.2004.04.026
关键词
farnesoid X receptor; microarray analysis; VLDL receptor; small interfering RNA
The farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs). In response to ligand-binding, FXR regulates many genes involved in BA, lipid, and lipoprotein metabolism. To identify new FXR target genes, microarray technology was used to profile total RNA extracted from HepG2 cells treated with the natural FXR agonist chenodeoxycholic acid (CDCA). Interestingly, a significant increase of transcript level of the very low density lipoprotein receptor (VLDLR) was observed. Our data, resulting from selective FXR activation, FXR RNA silencing and FXR-deficient mice, clearly demonstrate that BAs up-regulate VLDLR transcript levels via a FXR-dependent mechanism in vitro in human and in vivo in mouse liver cells. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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