期刊
ONCOGENE
卷 23, 期 24, 页码 4270-4274出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.onc.1207674
关键词
ETO; MTG8; repression; corepressor; HDAC
资金
- NHLBI NIH HHS [HL004339] Funding Source: Medline
- NIDDK NIH HHS [DK43806, DK45586] Funding Source: Medline
The 8; 21 translocation produces a fusion between the ETO gene and that encoding the myeloid transcription factor AML1. The AML1-ETO fusion substitutes the majority of the ETO protein for the coregulator recruitment domains of AML1. Biochemical analyses of ETO have led to the identification of numerous interacting proteins including many corepressors. Importantly, the proteins interacting with ETO are different from those of wild-type AML1, suggesting that altered coregulator recruitment underlies the oncogenic properties of AML1 - ETO. The list of corepressors capable of binding ETO includes histone deacetylases (HDACs) and components of distinct HDAC core complexes. These investigations have provided mechanistic insight into corepressor recruitment by ETO and clues to the leukemogenic activity of AML1 - ETO.
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