期刊
NEURON
卷 42, 期 4, 页码 595-605出版社
CELL PRESS
DOI: 10.1016/S0896-6273(04)00254-5
关键词
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资金
- NEI NIH HHS [R01 EY012031, P30 EY010608, R01 EY010542, R29 EY012128, EY-12031, R29 EY010542, R01 EY010542-08, EY-10608, EY-12128, EY-10542, R01 EY012128] Funding Source: Medline
Studies of the properties of synaptic transmission have been carried out at only a few synapses. We analyzed exocytosis from rod photoreceptors with a combination of physiological and ultrastructural techniques. As at other ribbon synapses, we found that rods exhibited rapid kinetics of release, and the number of vesicles in the releasable pool is comparable to the number of vesicles tethered at ribbon-style active zones. However, unlike other previously studied neurons, we identified a highly Call-sensitive pool of releasable vesicles with a relatively shallow relationship between the rate of exocytosis and [Ca2+], that is nearly linear over a presumed physiological range of intra-terminal [Ca2+]. The low-order [Ca2+] dependence of release promotes a linear relationship between Ca2+ entry and exocytosis that permits rods to relay information about small changes in illumination with high fidelity at the first synapse in vision.
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