期刊
SCIENCE
卷 304, 期 5675, 页码 1338-1340出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1095505
关键词
-
资金
- NCI NIH HHS [R01 CA081419] Funding Source: Medline
Neural stem cells are reported to lie in a vascular niche, but there is no direct evidence for a functional relationship between the stem cells and blood vessel component cells. We show that endothelial cells but not vascular smooth muscle cells release soluble factors that stimulate the self-renewal of neural stem cells, inhibit their differentiation, and enhance their neuron production. Both embryonic and adult neural stem cells respond, allowing extensive production of both projection neuron and interneuron types in vitro. Endothelial coculture stimulates neuroepithelial cell contact, activating Notch and Hes1 to promote self-renewal. These findings identify endothelial cells as a critical component of the neural stem cell niche.
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