期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 69, 期 11, 页码 3603-3609出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo040114j
关键词
-
资金
- NCI NIH HHS [CA78040] Funding Source: Medline
- NIDA NIH HHS [5 R01 DA09410] Funding Source: Medline
Combinatorial chemistry has deeply impacted the drug discovery process by accelerating the synthesis and screening of large numbers of compounds having therapeutic and/or diagnostic potential. These techniques offer unique enhancement in the potential identification of new and/or therapeutic candidates. Our efforts over the past 10 years in the design and diversity-oriented synthesis of low molecular weight acyclic and heterocyclic combinatorial libraries derived from amino acids, peptides, and/or peptidomimetics are described. Employing a toolbox of various chemical transformations, including alkylation, oxidation, reduction, acylation, and the use of a variety of multifunctional reagents, the libraries from libraries concept has enabled the continued development of an ever-expanding, structurally varied series of organic chemical libraries.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据