Anticonvulsant activity of Mimosa pudica decoction

The decoction of Mimosa pudica leaves given intraperitoneally at dose of 1000-4000 mg/kg protected mice against pentylentetrazol and strychnine-induced seizures. M. pudica had no effect against picrotoxin-induced seizures It also antagonized N-methyl-D-aspartate-induced turning behavior. These properties could explain its use in African traditional medicine. (C) 2004 Elsevier B.V. All rights reserved.