期刊
BRAIN AND COGNITION
卷 55, 期 1, 页码 41-53出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/s0278-2626(03)00284-7
关键词
orbitofrontal; basal ganglia; Parkinson's disease; addiction; psychopathy; risk taking
Converging evidence from human lesion, animal lesion, and human functional neuromiaging studies implicates overlapping neural circuitry in ventral prefrontal cortex in decision-making and reversal learning. The ascending 5-HT and dopamine neurotransmitter systems have a modulatory role in both processes. There is accumulating evidence that measures of decision-making and reversal learning may be useful as functional markers of ventral prefrontal cortex integrity in psychiatric and neurological disorders. Whilst existing measures of decision-making may have superior sensitivity, reversal learning may offer superior selectivity, particularly within prefrontal cortex. Effective decision-making on existing measures requires the ability to adapt behaviour on the basis of changes in emotional significance, and this may underlie the shared neural circuitry with reversal learning. (C) 2003 Elsevier Inc. All rights reserved.
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