期刊
CURRENT MEDICINAL CHEMISTRY
卷 11, 期 11, 页码 1513-1525出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867043365198
关键词
herb-drug interactions; pharmacokinetics; pharrnacodynamics; hypericuin perforation; Panax ginseng; Ginkgo bilobal; Glycyrrhiza glabra.
The increasing use of herbal medicinal products (HMPs) in the community where people are also receiving prescription medicines suggests that adverse herb-drug interactions may be of significant public health consequence. The evidence available to guide practitioners in decision making is complex and consists of a range of sources including adverse event database entries, spontaneous or case reports, in vivo and in vitro drug metabolism studies, and in vivo drug interaction studies in healthy subjects and patients. In the absence of further rigorous studies to assess the clinical significance of herb-drug interactions, an evidence-based appraisal of the current literature is essential to guide practitioners involved in patient care.
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