Enhancement of feeding suppression by PYY3-36 in rats with area postrerna ablations

We investigated suppression of food intake by intraperitoneal (IP) injections of peptide YY3-36 (PYY3-36) (24, 60, or 150 mug/kg) in rats with ablations of the area postrema (APX) and in controls with sham ablations. In controls, PYY3-36-induced suppression was modest and short-lived, averaging 20% at most and persisting less than 6 h. The highest dose tested (150 mug/kg) was even less effective than were the two lesser doses after 3 h. APX, did not diminish the potency of these effects of PYY3-36. In fact, the magnitude of suppression produced by the greatest dose Of PYY3-36 in APX rats was significantly greater than in controls and PYY3-36-induced suppression was still present at 24 It. (C) 2004 Elsevier Inc. All rights reserved.