期刊
ACS APPLIED MATERIALS & INTERFACES
卷 8, 期 6, 页码 3624-3634出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b07995
关键词
semiconducting polymer; nanoparticle; photosensitizer; energy transfer; photodynamic therapy
资金
- National Science Foundation of China [51173066, 61222508, 61335001]
- Thousand Young Talents Program
This paper described the energy-transfer amplified singlet oxygen generation in semiconductor polymer dots (Pdots) for in vitro and in vivo photodynamic therapy. Hydrophobic photosensitizer tetraphenylporphyrin was facilely doped in the nanoparticles consisting of densely packed semiconductor polymers. Optical characterizations indicated that the fluorescence of Pdots was completely quenched by the photosensitizer, yielding an energy transfer efficiency of nearly 100% and singlet-oxygen generation quantum yield of 50%. We evaluated the cellular uptake, dark toxicity, and photo dynamic therapy of the Pdot photosensizer in human gastric adenocarcinoma cells. The in vitro studies indicated that cancer cells were efficiently destroyed at very low dose of the Pdots such as 1 mu g/mL by using the light dose of 90 J/cm(2), which is considerably less than that in clinical practice. The antitumor effect of the Pdots was further evaluated in vivo with human gastric adenocarcinoma xenografts in Balb/c nude mice, which show that the xenograft tumors were significantly inhibited and eradicated in some cases. Our results indicate the energy transfer amplified Pdot platforms have great therapeutic potential for treating malignant cancers.
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