期刊
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
卷 16, 期 3, 页码 284-294出版社
AMER PSYCHIATRIC PUBLISHING, INC
DOI: 10.1176/appi.neuropsych.16.3.284
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资金
- NIMH NIH HHS [MH-19113, MH-31593, MH-40856, MH-CRC43271] Funding Source: Medline
A magnetic-resonance-imaging-based method of cortical parcellation was used to evaluate the morphology of the superior temporal plane and its subregions (Heschl's gyrus [HG], planum temporale [PT] and planum polare [PP]) in a group of 30 patients with schizophrenia versus a matched group of healthy subjects. Right HG volume was significantly reduced in patients compared with control subjects. Each subregion showed a unique set of structure/function relationships: reduced volumes of the HG were associated with greater duration of illness; reduced volumes of the PT were associated with positive symptoms; and in most contrast, elevated volumes of the PP were associated with cumulative neuroleptic exposure.
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