期刊
GENES AND IMMUNITY
卷 5, 期 4, 页码 313-314出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.gene.6364092
关键词
interleukin 10; pre-eclampsia; pathofysiology; pregnancy
Recently, it has been described that human fertility is associated with the interleukin 10 (IL10) -2849 AA genotype. Preeclampsia is the most common pregnancy-specific complication. In the pathogenesis of pre-eclampsia, IL10 may affect maternal intra vascular inflammation as well as endothelial dysfunction. Therefore, we tested the hypothesis that pre-eclampsia is associated with genetic variation in the IL10 promoter region in a case-control study for pre-eclampsia. Women homozygous for the IL10-2849A allele have a threefold reduced risk for pre-eclampsia compared to controls (odds ratio 0.29; 95% CI 0.10-0.83). No differences in genotype frequency were found for polymorphisms in the IL10 promoter region at positions -1082, -819 and -592. This suggests that there is a genetically determined mechanism which protects the mother against pre-eclampsia, as reflected in the lower frequency of the IL10-2849AA genotype in pre-eclamptic women.
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