4.7 Article Proceedings Paper

Influence of PAMAM dendrimers on human red blood cells

期刊

BIOELECTROCHEMISTRY
卷 63, 期 1-2, 页码 189-191

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ELSEVIER SCIENCE SA
DOI: 10.1016/j.bioelechem.2003.09.023

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PAMAM dendrimers; erythrocytes; morphology; haemolysis; toxicity

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Polyamidoamine (PAMAM) dendrimers with different concentrations (1 nM-1 mM) (generations 2, 3, and 4) impact on human red blood cell morphology, and membrane integrity is studied. Erythrocyte shape changes from biconcave to echinocytic in dendrimers. Cell aggregation occurs. Polymers cause also concentration- and generation-dependent haemolysis. (C) 2004 Elsevier B.V. All rights reserved.

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