期刊
BRITISH JOURNAL OF DERMATOLOGY
卷 150, 期 6, 页码 1198-1201出版社
WILEY
DOI: 10.1111/j.1365-2133.2004.05993.x
关键词
cytokines; immune response modifiers; primary cutaneous lymphoma; treatment
类别
CD30+ anaplastic large cell lymphoma is a primary cutaneous lymphoproliferative disorder with a high rate of spontaneous regression (almost 25%). The suggested therapies are radiation, surgery and methotrexate. We describe two patients with nonregressing primary cutaneous CD30+ T-cell lymphoma that was successfully treated with topical imiquimod 5% cream (Aldara(R), 3M) three times weekly for 6 weeks. In both cases we obtained complete clinical remission, confirmed by histology. No recurrences were observed during the following 8 months. We consider that topical application of an immune response modifier, such as imiquimod, could be a good alternative to other potentially more dangerous or aggressive treatments.
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