期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 32, 期 -, 页码 496-498出版社
PORTLAND PRESS
DOI: 10.1042/BST0320496
关键词
apoptosis; granuloma; macrophage; mycobacterium; tuberculosis; virulence
Macrophage apoptosis occurs within the granuloma, which is essential for successful immunity to tuberculosis. In vitro macrophage apoptosis is associated with the killing of intracellular Mycobacterium tuberculosis. A greater understanding of these observations will lead to new immunotherapies and improved vaccine design. The relevant apoptotic stimuli, the anti-mycobacterial mechanisms that they stimulate and their physiological relevance are reviewed in this paper.
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