期刊
BEHAVIORAL NEUROSCIENCE
卷 118, 期 3, 页码 479-487出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.118.3.479
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资金
- NIDA NIH HHS [R21 DA 14545] Funding Source: Medline
- NIDDK NIH HHS [R01 DK 40963] Funding Source: Medline
- NIMH NIH HHS [R03 MH 65353] Funding Source: Medline
The authors hypothesized that insulin and leptin, hormones that convey metabolic and energy balance status to the central nervous system (CNS), decrease the reward value of food, as assessed by conditioned place preference (CPP). CPP to high-fat diet was blocked in ad-lib fed rats given intraventricular insulin or leptin throughout training and test or acutely before the test. Insulin or leptin given only during the training period did not block CPP. Thus, elevated insulin and leptin do not prevent learning a food's reward value, but instead block its retrieval. Food-restricted rats receiving cerebrospinal fluid, insulin, or leptin had comparable CPPs. Results indicate that the CNS roles of insulin and leptin may include processes involving memory and reward.
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