期刊
INTERNATIONAL IMMUNOPHARMACOLOGY
卷 4, 期 6, 页码 713-720出版社
ELSEVIER
DOI: 10.1016/j.intimp.2004.02.006
关键词
resveratrol; PMA-differentiated THP-1 cell; CD14; interferon gamma; lipopolysaccharide
Resveratrol, a polyphenol compound found in grapes and red wines, is a prominent anti-cancer agent. In this study, we demonstrate that resveratrol enhanced TNF-alpha, IL-12 and IL-1beta production from LPS activated phorbol myristate acetate (PMA) differentiated THP-1 human macrophages. Expression of CD86 on macrophages was enhanced by resveratrol alone and with LPS. When macrophages were primed with IFN-gamma, resveratrol suppressed the expression of HLA-ABC, HLA-DR, CD80, CD86 and inhibited production of TNF-alpha, IL-12, IL-6 and IL-1beta induced by LPS. The differential impact of resveratrol on expression of CD14 might be correlated with differential response of macrophages to LPS with or without IFN-gamma priming. (C) 2004 Elsevier B.V. All rights reserved.
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