期刊
AQUACULTURE NUTRITION
卷 17, 期 6, 页码 595-604出版社
WILEY-HINDAWI
DOI: 10.1111/j.1365-2095.2011.00853.x
关键词
antioxidant enzymes; Cyprinus carpio var. Jian; lipid peroxidation; MHA; oxygen radicals; protein oxidation
类别
资金
- Sumitomo-chemical (Japan)
- National Science Foundation of China [30771671, 30871926]
- Programme for New Century Excellent Talentsin University [NCET-08-0905]
- Chinese Ministry of Education [208120]
- Sumitomo-chemical
Oxidative damage and antioxidant status of intestine and hepatopancreas for juvenile Jian carp (Cyprinus carpio var. Jian) fed graded levels of methionine hydroxy analogue (MHA: 0, 5.1, 7.6, 10.2, 12.7, 15.3 g kg(-1) diet) for 60 days were studied. Radical scavenging ability, antioxidant enzymes activities such as superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPX) and glutathione reducase (GR), as well as glutathione (GSH), protein carbonyl (PC) and malondialdehyde (MDA) contents were assayed in these tissues. Results indicated that anti-superoxide anion capacity in intestine and anti-hydroxyl radical capacity in hepatopancreas significantly improved with dietary MHA levels up to 7.6 and 10.2 g kg(-1) diet respectively, whereupon they decreased (P < 0.05). SOD, CAT, GST, GPX, GR activities in intestine and hepatopancreas, as well as GSH content in hepatopancreas significantly increased with optimal MHA levels which were in the range of 5.1-10.2 g kg(-1) diet, and thereafter decreased (P < 0.05). Meanwhile, MDA and PC contents in these tissues together with GOT and GPT activities in plasma significantly decreased with optimal MHA levels which were in the range of 5.1-7.6 g kg(-1) diet, and thereafter increased (P < 0.05). These results suggested that MHA improved antioxidant status and depressed lipid and protein oxidation in intestine and hepatopancreas.
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