期刊
ENDOCRINE-RELATED CANCER
卷 11, 期 2, 页码 255-263出版社
BIOSCIENTIFICA LTD
DOI: 10.1677/erc.0.0110255
关键词
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资金
- NCI NIH HHS [R01-CA77612] Funding Source: Medline
Copper is a tightly regulated trace element. Disruptions of copper homeostasis are rare and they cause serious disorders such as Wilson's disease and Menkes disease. Copper also plays an important role in promoting physiological and malignant angiogenesis. Formation of new blood vessels by a tumor enables tumor growth, invasion and metastasis. The copper chelator tetrathiomolybdate (TM), which quickly and effectively depletes copper stores, is under investigation as an anti-angiogenic agent. Promising results in vitro, in pre-clinical animal models and in an early (phase 1) clinical trial have led to ongoing phase 11 evaluation of TM in patients with advanced cancers.
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