期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 48, 期 6, 页码 2305-2307出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.48.6.2305-2307.2004
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The dimorphic fungus Candida albicans excretes farnesol, which is produced enzymatically from the sterol biosynthetic intermediate farnesyl pyrophosphate. Inhibition of C. albicans by four azole antifungals, Huconazole, ketoconazole, miconazole, and clotrimazole, caused elevated farnesol production (10- to 45-fold). Furthermore, farnesol production occurs in both laboratory strains and clinical isolates (J. M. Hornby et al., Appl. Environ. Microbiol. 67:2982-2992, 2001) of C. albicans.
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