期刊
STRAHLENTHERAPIE UND ONKOLOGIE
卷 180, 期 6, 页码 365-370出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00066-004-1191-8
关键词
soft tissue sarcoma; intraoperative radiotherapy; radiotherapy; functional outcome; local tumor control
Purpose: Evaluation of treatment outcome after intraoperative radiotherapy (IORT) +/- external-beam irradiation (EBRT) in patients with Localized soft tissue sarcoma of the extremity at high risk for Local recurrence after Limb-sparing surgery. Patients and Methods: 28 patients treated between 1989 and 1999 were evaluated retrospectively. Patients presented with locally recurrent (n = 17), T2 (n = 20), high-grade (n = 26), or incompletely resected tumors (n = 11). All patients underwent limb-sparing surgery and IORT (median dose of 15 Gy) given either with high-dose-rate brachytherapy or a linear accelerator. 25 patients received additional EBRT with a mean of 50.6 Gy (range: 30.6-60 Gy). The mean follow-up time was 4.3 years (95% confidence interval [CI]: 3.0-5.6 years). Results: The 5-year overall and distant disease-free survival rates were 66% and 54%, respectively. The overall actuarial recurrence rate after 5 years is 16% (95% CI: 1%, 31%). The crude rate after 8 years is 18%. Surgical margin status, primary versus recurrent tumor and tumor stage did not show any statistically significant influence (univariate analysis) on local recurrence rates. Patients with T1 tumors exhibited a borderline significant (p = 0.053) better distant disease-free survival (83%) compared to T2 tumors (43%). Five (24%) grade 3-4 late side effects were observed. Conclusion: In patients with high-risk soft tissue sarcomas, IORT EBRT after Limb-preserving surgery achieves high local control rates. The risk of normal tissue toxicities is comparable to conventional Limb-sparing treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据