期刊
CURRENT DRUG METABOLISM
卷 5, 期 3, 页码 225-234出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389200043335540
关键词
cytochrome P450; eicosanoids; EETs; neurosteroids; estrogen; cerebral ischemia; preconditioning; neuroprotection
资金
- NHLBI NIH HHS [P01 HL59996] Funding Source: Medline
- NINDS NIH HHS [R01 NS33668, R01 NS044313, R01 NS44313] Funding Source: Medline
Advances in a multitude of disciplines support in emerging role for cytochrome P450 enzymes and their metabolic substrates and end-products in the pathogenesis and treatment of central nervous system disorders. including acute cerebrovascular injury. such as stroke, chronic neurodegenerative disease. Such as Alzheimer's and Parkinson's disease. as well as epilepsy. Multiple sclerosis and psychiatric disorders, including anxiety and depression. The neural tissue contains its own unique set of P450 genes that are regulated in a manner that is distinct from their molecular regulation in peripheral tissue. furthermore. brain P450s catalyze the formation of important brain signaling such as neurosteroids and eicosanoids, and metabolize substrates as diverse as vitamins A and D, cholesterol, bile acids, as well as centrally acting drugs, anesthetics and environmental neurotoxins. These unique characteristics allow this Family of proteins and their metabolites to perform such vital functions in brain as neurotrophic support, neuroprotection control of cerebral blood flow, temperature control, neuropeptide release, maintenance of brain cholesterol homeostasis. elimination of retinoids from CNS, regulation of neurotransmitter levels and other functions important in brain physiology, development and disease.
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