期刊
EXPERT OPINION ON BIOLOGICAL THERAPY
卷 4, 期 6, 页码 837-846出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.4.6.837
关键词
asthma therapeutics; atopy; CD4; cytokines; immunomodulation; interleukin-16
The therapeutic potential of interleukin (IL)-16 and derived peptides in allergic asthma is considered, focusing on key interactions with CD4 and associated chemokine receptors. IL-16 is a pleiotropic cytokine that has multiple effector functions with putative roles in varied T cell-mediated inflammatory diseases, such as asthma, inflammatory bowel disease and atopic dermatitis. Both in vitro and in vivo, IL-16 downregulates antigen-driven T cell activation, T helper 2 cytokine production and allergic airway inflammation. Peptides derived from the C-terminal bioactive portion of IL-16 offer advantages related to their retained immunomodulatory properties and absence of signalling in and chemoattraction to T cells.
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