期刊
NEUROPSYCHOPHARMACOLOGY
卷 29, 期 6, 页码 1190-1202出版社
SPRINGERNATURE
DOI: 10.1038/sj.npp.1300420
关键词
dopamine; [C-11]raclopride; PET
资金
- NCRR NIH HHS [M01RR00645] Funding Source: Medline
- NIDA NIH HHS [PA50 DA 09236-06, 2-R01-DA10219-01, K08 DA00483-01] Funding Source: Medline
Striatal dopamine D-2 receptors have been implicated in the neurobiology of cocaine addiction. Previous imaging studies showed reduced striatal D-2 receptor availability in chronic cocaine abusers, and animal studies suggested that low D-2 receptor availability promotes cocaine self-administration. Here, D-2 receptor availability was assessed with positron emission tomography (PET) and [C-11]raclopride in the limbic, associative, and sensori-motor subdivisions of the striatum in 17 recently detoxified chronic cocaine-dependent (CCD) subjects and 17 matched healthy control (HC) subjects. In addition, the relationship between regional D-2 receptor availability and behavioral measures obtained in cocaine self-administration sessions was investigated in CCD subjects. [C-11]Raclopride binding potential was significantly reduced by 15.2% in the limbic striatum, 15.0% in the associative striatum, and 17.1% in the sensori-motor striatum in CCD subjects compared to HC subjects. In CCD subjects, no relationship was detected between D-2 availability in striatal regions and either the positive effects of smoked cocaine or the choice of cocaine over an alternative reinforcer (money) following a priming dose of cocaine (a laboratory model of relapse), Thus, this study confirms previous reports of a modest decrease in D-2 receptor availability in CCD subjects, and establishes that this decrease is generalized throughout the striatum. However, this study failed to demonstrate a relationship between D-2 receptor availability and cocaine-induced cocaine-taking behavior. Additional research is warranted to unravel potential neurobiological traits that might confer vulnerability to relapse in detoxified CCD subjects.
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