期刊
PARASITE IMMUNOLOGY
卷 26, 期 6-7, 页码 265-272出版社
WILEY
DOI: 10.1111/j.0141-9838.2004.00705.x
关键词
antibody; longitudinal study; malaria; Plasmodium falciparum; synthetic peptide; vaccine
A longitudinal study was undertaken in Burkina Faso among 293 children aged 6 months to 9 years in order to determine the correlation between an antibody response to several individual malarial antigens and malarial infection. It was found that the presence of a positive antibody response at the beginning of the rainy season to three long synthetic peptides corresponding to Plasmodium falciparum Exp-1 101-162, MSP-3 154-249 and GLURP 801-920 but not to CSP 274-375 correlated with a statistically significant decrease in malarial infection during the ongoing transmission season. The simultaneous presence of an antibody response to more than one antigen is indicative of a lower frequency of malarial infection. This gives scientific credibility to the notion that a successful malaria vaccine should contain multiple antigens.
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